51 Top Interview Questions for Quality Control (QC) in Pharma

Quality control in pharmaceuticals involves the testing of all new or existing products. It becomes important to know the questions related to quality control to get a dream job in the quality section. If you are a graduate in pharmacy or a master in science, then before the interview you can read all the Interview Questions for Quality Control department so that it becomes easy to give all the answers and get your dream jobs.

Interview Questions for Quality Control

Important interview Questions for Quality Control analyst

1. Question: Define pH? What is the pH of the blood?

Ans: pH is the negative logarithm of H+ Concentration. The pH of the blood ranges from 7.35 to 7.45.

2. Question: Explain the terms aliquot and diluent?

Ans: Aliquot: Aliquot is a measured sub-volume of the original sample.

Diluent: the component used to dilute the sample.

3. Question: Explain what is titration?

Ans: Titration is also called volumetric analysis. It is a quantitative chemical analysis used to determine the concentration of an analyte that has been identified. The titrator is a reagent that is prepared as a standard solution with a known concentration and volume. The titrant reacts with the analyte solution to determine the concentration of the analyte. The titration volume is the amount of titrant that reacts with the analyte.

4. Question: Types of titration?

Ans: There are basically four types of titration, acid-base titration, complexometric titration, precipitation titration, and redox titration.

5. Question: Explain the four types of titration

Ans: Acid-base titration: in this acidic or basic titrant reacts with an analyte that is base or an acid.

Complexometric titrations: involving metal-ligand complexation reactions

Precipitation titrations: When the analyte and titrant react, a precipitate is formed.

Redox titrations: Where the titrant is oxidizing agents or reducing agents.

6. Question: What is the Ultraviolet (UV) and visible spectroscopy range?

Ans: The range of UV Spectroscopy is 200-400 nm, and visible spectroscopy ranges from 400- 800 nm.

7. Question: What is the use of UV Spectroscopy?

Ans: Spectroscopy can be used to detect functional groups, impurities, and perform qualitative and quantitative analyses.?

8. Question: What is meant by the solution?

Ans: A solution is a mixture of liquids, gases, and solids, the solution consists of many different types of solutes like salts, oxygen, and organic molecules.

9. Question: Describe the saturated and unsaturated solutions

Ans: A saturated solution is defined as a solution in which a solvent is not capable of dissolving any more solute at a given temperature.

At a given temperature, an unsaturated solution is one in which the solvent is capable of dissolving any extra solute.

10. Question: What is the difference between qualitative and quantitative analysis?

Ans: Qualitative analysis involves the identification of the compound or chemical-based on their chemical ( absorption, emission) or physical properties, eg. melting point and boiling point.

Quantitative analysis: this involves estimation or determination of concentration or amount of the chemical compounds or components.

Interview Questions for Quality Control related to UV Spectroscopy

Interview Questions for Quality Control under UV Spectroscopy is given below:

11. Question: Explain the principle of ultraviolet spectroscopy?

Ans: Ultraviolet spectroscopy uses light in the UV part of the electromagnetic spectrum.  UV absorption spectra form when the outer electrons of a molecule or an atom absorb energy and move from a lower to a higher energy level. The wavelength absorbance of each molecule is unique.

12. Question: Define Molarity?

Ans: A number of moles of solute per liter solution. molarity is denoted with a capital “M”.

13. Question: Define molality?

Ans: The number of moles of solute per kilogram solvent. it is denoted with a small “m”.

14. Question: Define normality?

Ans: The number of moles equivalent per liter solution.

15. Question: What are buffer solutions?

Ans: A buffer solution is an aqueous solution consisting of a mixture of a weak acid and its conjugate base, or vice versa. When a minimal amount of strong acid or base is introduced to it, the pH changes very little.

16. Question: What is valency?

Ans: Valency is simply the combining power of elements. the valency determines the chemical formula of a compound. When compounds react to form new compound (s) they tend to change their valences.

17. Question: What is aqua regia?

Ans: A mixture of concentrated nitric acid and hydrochloric acids. (1:3) It’s a highly corrosive liquid that can harm gold and other hardened materials.

18. Question: What is bleaching powder’s chemical name?

Ans: Calcium hypochlorite, also known as CaOCl2, is an inorganic chemical compound having the formula CaOCl2. Calcium oxychloride is another name for them.

19. Question: What is polarity?

Ans: Polarity is the electronegativity difference between the atom or molecule or the ability of an atom to attract shared electrons in a covalent bond. Ans: Water is a good example of a polar molecule due to the difference in the electronegativity between the oxygen atom and the hydrogen. Oxygen is a highly electronegative atom compared to hydrogen. Because fats, petrol, and gasoline do not dissolve in water, they are classified as non-polar molecules. Nonpolar means “insoluble in water.”

20. Question: Explain the Beer Lamberts Law?

Ans: It states that the intensity of nonchromatic light absorbed by a substance dissolved in a fully transmitting solvent is directly proportional to the substance concentration and the path length of the light through the solution.

21. Question: What is an indicator in chemistry?

Ans: Indicators are substances that show a change in color when brought in contact with acid or base. The most commonly used indicators are litmus, methyl orange, phenolphthalein that change color as follows.

indicator color changes table quality control chemistry

Top interview questions for quality control in manufacturing

22. Question: Explain the Infrared Spectroscopy Principle?

Ans: When a molecule absorbs the infrared radiation, it vibrates and gives rise to a packed infrared absorption spectrum. This IR spectrum is specific for every different molecule absorbing the IR radiation, useful for identification.

23. Question: What is the common alum?

Ans: Potassium alum, potash alum, or potassium aluminum sulfate is a chemical compound Chemical formula of common alum is KAI(SO4)2.12H2O. Use water purification.

24. Question: What is a covalent bond?

Ans: A covalent bond also called a Molecular bond is a chemical bond that involves the sharing of electron pairs between atoms.

25. Question: Mention the formula to calculate the pH of a solution?

Ans: Formula to calculate pH = -log [H+] or pH = -log [H3O+]

26. Question: What is PPM?

Ans: PPM is parts per million (such as % means parts per 100)

27. Question: What is The HPLC Principle?

Ans: It’s technically used for separating the mixture of compounds into individual components based on absorption, partition, ion exchange, and size exclusion principles. The stationary phase and mobile phase are used in it. HPLC is used for the identification, quantification, and purification of components from a mixture.

28. Question: Explain what is dextro-rotatory and levorotatory?

Ans: Levorotation and Dextrorotation are referred to as the properties of plane-polarized light when light rotates clockwise when it approaches the observer are then known as dextro-rotatory, and when light rotates anticlockwise then it’s referred to as levorotatory.


These all Questions are very important for usually, who are preparing for interviews in the quality control (QC) section in pharmaceuticals. Hope these Interview Questions for Quality Control with answers will be helpful. if any updates or doubts please reply below.

Note: All above Answers to Interview questions for Quality control will be updated from time to time whenever changes will happened in methods or formulas.

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