1. Jhnson & Johnson Location: New Brunswiock, NJ 2021 Market Cap $93.77 billion

Consistently ranked as the largest pharmaceutical company in the United States and the largest pharmaceutical company in the world

2. Pfizer Location: New York City, NY 2021 Market Cap $81.28 billion Charles Pfizer and his cousin Charles Erhart founded the company in the mid-1800s.

3. AbbVie  Location: Lake Bluff, IL 2021 Market Cap $56.197 billion AbbVie was originally one of two companies formed by the division of Abbot Laboratories.

4. Bristol-Myers Squibb Location: New York City, NY 2021 Market Cap $46.385 billion Bristol-Myers Squibb, a pharmaceutical company based in New York City, was founded in the mid-1800s

5. Abbott Location: Lake Bluff, IL 2021 Market Cap $43.075 billion

6. Merck ; Co. Location: Kenilworth, NJ 2021 Market Cap $39.121 billion

7. Stryker Location: Kalamazoo, MI 2021 Market Cap $17.1 billion

8. Regeneron Pharmaceuticals Location: Tarrytown, NY 2021 Market Cap $16.072 billion

9. Biogen Location: Cambridge, MA 2021 Market Cap $10.982 billion

10. Eli Lilly and Company Location: Indianapolis, IN 2021 Market Cap $2.239 billion